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In the COMBINE 2 trial in individuals with T2D inadequately controlled with GLP-1RA, with or without additional oral glucose-lowering medications, IcoSema as compared to semaglutide 1.0 mg provided superiority in HbA 1c reduction from baseline to week 52 and greater improvement in fasting plasma glucose with comparable rate of combined clinically significant or severe hypoglycemia, while the weight change was in favor of semaglutide 1.0 mg [14]

Hepatology 41 (6), 13131321 (2005)

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Non-Essential Amino Acids Non-essential amino acids are those that the body can produce naturally , even if they are not obtained directly from food